Predicting antibiotic resistance, not just for quinolones
نویسندگان
چکیده
منابع مشابه
Predicting Antibiotic Resistance, Not Just for Quinolones
The ability to better understand and predict the onset of antibiotic resistance to new drugs is needed. Antibiotic resistance has become an emerging issue of concern, and there are emphases to minimize its escalation. The number of cases of antibiotic resistant infections is increasing, as are the numbers of multidrug resistant bacteria. As a result, more antibiotics are becoming of limited use...
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Cutting-edge machine learning tools have shown significant promise for infectious disease control using the bacterial genome. In this chapter, an overview of key problems of clinical microbiology surrounding infectious disease management, antibiotic resistance, and clinical susceptibility test to antimicrobial drugs, will be provided, followed by an introduction of genomic data used in genotypi...
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Ohno, H., Koga, H., Kohno, S.. Higashiyama, Y., Miyazaki, Y., Ogawa, K., Yanagihra, K., Yamamoto, Y., Noda, T. & Miyamoto, J. (1994), Evaluation for rapid detection of rifampiein-rcsistant MycobacteHum tuberculosis by polymerase chain reaction-single strand conformation polymorphism. Kekkaku, 69, 773-778. Predieh, M., Doukhan, L., Nair, G. & Smith, I. (1995), Characterization of RNA polymerase ...
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The quinolones trap DNA gyrase and DNA topoisomerase IV on DNA as complexes in which the DNA is broken but constrained by protein. Early studies suggested that drug binding occurs largely along helix-4 of the GyrA (gyrase) and ParC (topoisomerase IV) proteins. However, recent X-ray crystallography shows drug intercalating between the -1 and +1 nucleotides of cut DNA, with only one end of the dr...
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The increased use of fluoroquinolones has led to increasing resistance to these antimicrobials, with rates of resistance that vary by both organism and geographic region. Resistance to fluoroquinolones typically arises as a result of alterations in the target enzymes (DNA gyrase and topoisomerase IV) and of changes in drug entry and efflux. Mutations are selected first in the more susceptible t...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2011
ISSN: 1664-302X
DOI: 10.3389/fmicb.2011.00178